Observou-se um caso de resistência à eritropoetina recombinante humana causada por Ectasia Vascular Antral Gástrica em uma mulher de 40 anos de idade. Abstract. DAL MASO, Rosina Conceição Graçaplena et al. Sex hormones in women on dialysis. Rev. Assoc. Med. Bras. [online]. , vol, n.4, pp . 22 out. Observou-se um caso de resistência à eritropoetina recombinante humana causada por Ectasia Vascular Antral. Gástrica em uma mulher de.

Author: Tojarn Fenrilabar
Country: El Salvador
Language: English (Spanish)
Genre: Relationship
Published (Last): 19 July 2010
Pages: 346
PDF File Size: 1.2 Mb
ePub File Size: 10.47 Mb
ISBN: 754-7-95517-283-4
Downloads: 8929
Price: Free* [*Free Regsitration Required]
Uploader: Vuzilkree

Similarly, it may play an important role reducing CKD oxidative stress and vascular dysfunction. Whereas that RDW Hematopoietic and cytoprotective functions Erythropoietin is an endocrine, paracrine and autocrine erritropoetina that acts as a cytoprotective hormone overextending its haematopoietic function.

In this work, based on a literature search of studies humaha MEDLINE, our objective is to review the regulation of erythropoietin production and its functions, as recimbinante as treatment approach for anaemia of chronic kidney disease, with particular focus on new therapies. However, spiegelmers administration leads to oligonucleotides accumulation in macrophages, throughout the body, being unknown whether this chronic systemic administration results in adverse effects Regular transfusions increased the risk of infection, iron overload and anti-HLA human leukocyte antigen antibodies development, reducing the likelihood of a successful renal transplantation.


Regulação da produção da eritropoietina e perspectivas terapêuticas na anemia

InNagai et al. The main effort in developing these treatments is to achieve other routes of administration, more convenient for the patient, such as oral therapy, not disregarding an easier production, storage and frequency of administration. During fetal life, EPO is produced by the liver. Erythropoietin protects against ischaemic acute renal injury.

Nephrol Dial Transplant ; These sequences are found in regulatory regions of various genes, oxygen sensitive, and are called the hypoxia response elements HRE 2.

Fung E, Nemeth E. The production by peritubular cells occurred under hypoxic conditions, suggesting a different regulation mechanism between the nephrons recombibante peritubular cells 5.

Sign in to the Lens

In recmbinante phase I trial, NOX-H94 administration was safe and well tolerated, and after a single dose, there was a dose-dependent increase in serum iron and transferrin saturation.

Erythropoiesis stimulating agents ESA: It is a hyperglycosylated EPO analogue with a higher number of sialic acid residues, which improves its biological potency.

Kidney Int ;78 9: Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization. Epoetin treatment of anemia associated with cancer therapy: Since then, several ESAs have appeared, characterized by lower administration frequency and better stabilization of haemoglobin concentration.


Lipocalins are small extracellular proteins that exhibit a binding site with high structural plasticity. The findings of the second upper-gastrointestinal endoscopy were normal appearance of the pylorus and longitudinal antral folds containing visible stripes of tortuous red ecstatic vessels with bleeding watermelon stomach- Figure 1.

Kidney Int ;67 4: In monkeys, its administration resulted in effective iron mobilization, with increased serum levels Androgen versus erythropoietin for the treatment of anemia in hemodialyzed patients: It acts simultaneously on erythrocytes production and erigropoetina incorporation, correcting anaemia and maintaining haemoglobin levels without needing IV iron supplementation, in pre-dialysed or dialysed patients.

Peginesatide for anemia in patients with chronic kidney disease not receiving dialysis. Nephrol Dial Transplant ;19 2: However, based on experience reported in the literature for patients with GAVE undergoing therapy with APC appropriate monitoring is required. Am J Pathol ; 4: Erythropoietin receptormediated inhibition of exocytotic humanq release confers neuroprotection during chemical ischemia. There were no esophageal varices. Erythropoietin EPOformerly named haemopoietin is essential to erythropoiesis.

We did not observe any squizocytes.

Author: admin