Classics in Total Synthesis. By K.C. Nicolaou and E. J. Sorensen. Article (PDF Available) in Molecules 3(2) · February with 2, Reads. This book is essential for any synthetic organic chemist.[ ]. K. C. NICOLAOU, E. J. SORENSEN. CLASSICS IN. TOTAL. Page 2. Classics in Total Synthesis K. C. Nicolaou and. – E. J. Sorensen. VCH.

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After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Scripps Research Institute under the guidance of Professor K. A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists. It is a large joy to read “Classics in Total Synthesis”, even if one must ask himself amazedly if he had come on such ingenious synthesis ways.

After describing retrosyntheses that have been achieved, and any preliminary synthetic work, the chapter gives a very detailed description of the synthesis of the target structure, including almost all the individual steps. Site Search any all words Main Categories. All the key steps of the synthetic pathway are explained, with major developments highlighted in blue boxes.

The very instructive concept of discussing and comparing several different syntheses of a target structure in a parallel fashion, which was introduced in the second volume of this series, has now been further developed in a clever way. He is the recipient of many prizes, awards and honors. This book is a must for every synthetic chemist. These kind of informations are presented in form of an interesting introduction before the synthesis is presented.

This alone is one of the great strengths of the book, and provides every synthetic chemist with an excellent pool for the solution of his or her own synthetic problems.


Novelties of this third volume compared to the previous ones are mainly concerned with the detailed classicss. Nicolaou compiles here the important strategies and tools employed to construct complex molecules. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. Short Description Using his didactically skillful approach, Claseics.

Wiley-VCH – Classics in Total Synthesis III

A wonderful tool for learning and teaching and a must-have for all current and future organic and biochemists. Clasics, Strategies, Methods K. Numerous references to useful reviews and the original literature make this book an indispensable source of further information.

Added to Your Shopping Cart. The depth of mechanistic discussions has been greatly increased.

Every synthetic organic chemist will want to have a copy on his or her desk. Thus, one finds surveys on current topics of interest such as organocatalysis Chapter 7: The present volume – and hopefully future books of this series – offer an exciting and outstanding overview of the subject of natural products total syntheses in its complexity and variety.

Nicolaou has made outstanding contributions in his research field. His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology described in numerous publications and patens.

This series can therefore already be justifiably called a classic in itself. With didactic skill and clarity, K.

Important reactions are additionally deepened. Excellent graphics and two colours throughout: All literature references are clearly identified by chapter endnotes, thus allowing rapid access to the primary sources. He currently is a post-doctoral fellow in Professor Nicolaou’s laboratory.

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Classics in Total Synthesis

It is amazing, as in the 50’s, how projects like the synthesis of penicillin were advanced. The book includes the years to and is for this reason, both, a kind of historical book and a reference book. The review of asymmetric halogenation reactions Chapter The selected examples cover a large range of methods and very important natural products. The authors carefully explain each synthetic step and give hints tofal alternative methods and potential pitfalls.


The chapter ends with a short summary and a well-chosen, detailed, and extensive list of references. Description Content Reviews Author information Retaining his excellent, proven approach, world-famous chemist and passionate teacher K. One innovation is the introduction of a colored title page at the beginning of each chapter, presenting an attractive graphical illustration of the target structure, together with its natural source and a picture of the leader of the group that worked on the total synthesis.

For easy reference, key intermediates are also shown in the margins.

Book Review: Classics in Total Synthesis – K. C. Nicolaou, E. J. Sorensen

Likewise, the third volume of this series, published by Wiley-VCH in Februarywill surely continue the success of the previous volumes, and will certainly be a must-have in the libraries of synthetically orientated groups.

Such explanations, and possibly also descriptions of unsuccessful attempted routes, could give the reader an even more detailed insight into problems of reactivity or selectivity of a specific reagent or substrate. Reaction sequences and synthetically crucial steps are presented in blue boxed sections.

Read the press announcement: About the Author K. In contrast to the first two volumes, this new one features full-color frontispieces. As the selection of synthetic target molecules for this book is exclusively totla from the more recent literature, in contrast to the first volume of the series, it remains to be seen whether the syntheses described will eventually become true classics.

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