Erythema elevatum diutinum (EED) is a rare, chronic dermatosis that is characterized by red–violet to red–brown papules, plaques, and. Erythema elevatum diutinum (EED) is a chronic form of leukocytoclastic vasculitis consisting of violaceous, red-brown, or yellowish papules. Erythema elevatum diutinum. Authoritative facts about the skin from DermNet New Zealand.

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On exam, lesions of EED present as red—brown, yellowish, or violaceous papules, plaques, or nodules.

It is believed that such an association results from the HIV antigen-antibody interaction, which causes direct damage to vessel walls. Rare disease; unknown incidence. They typically are symmetrically distributed and favor acral and periarticular sites, specifically the extensor surfaces of the elbows, knees, ankles, hands, and fingers. EED in the setting of HIV infection is characterized by nodular lesions, used palmoplantar, that progress to form bulky masses.

Initially, the lesions are erythematous and soft but with time become red—brown or violaceous in color and firm to palpation secondary to fibrosis. It is probably mediated by immune complexes. EED is classified as a small vessel vasculitis. Erythema elevatum diutinum is a chronic and rare dermatosis that is considered to be a variant of leukocytoclastic vasculitis.

The severity of EED does not, however, appear to be dependent on the total paraprotein levels. Extracutaneous symptoms include arthralgia, fever, or other constitutional symptoms.

Spontaneous resolution often occurs after 5 to 10 years. One month after diagnosing HIV infection, the patient presented a neurological condition of right-side motor impairment.


Erythema elevatum diutinum treated with niacinamide and tetracycline. Erietma within a content type, and even narrow to one or more resources. It is also ineffective in nodular lesions, elwvatum to the fibrosis of the lesions. Adult with red-brown nodules and plaques. Erythema elevatum diutinum – a solitary lesion in a patient with rheumatoid arthritis.

Arteriovenous malformation Bonnet—Dechaume—Blanc syndrome Cobb syndrome Parkes Weber syndrome Sinusoidal hemangioma lymphatic malformation Hennekam syndrome Aagenaes syndrome telangiectasia: A year old male Caucasian patient, born and residing in Campinas, had a history of hyperchromic macules, bilaterally located in the medial and lateral malleolar zone of the ankles and on the heels and dorsal aspect of the feet.

How to cite this article. EED is a chronic and progressive skin disease that may last as long as 25 eoevatum. Although the etiology of EED is unknown, circulating immune complexes, with repeated deposition, associated inflammation, and partial healing are thought to represent the underlying pathogenesis.

Erythema elevatum diutinum EED is a chronic leukocytoclastic vasculitis LCV that was initially described by Hutchinson in and subsequently by Bury in Extracellular cholesterol deposits may be observed in the fibrotic tissue. Please enter Password Forgot Username? This page was last edited on 2 Eritwmaat In other projects Wikimedia Commons. Erythema elevatum diutinum Capillaritis Urticarial vasculitis Nodular vasculitis.

Eritema elevatum diutinum as a differential diagnosis of rheumatic diseases: case report.

Nevertheless, immunoelectrophoresis screening for monoclonal gammopathies as a marker of EED has been recommended. We report on the case of a patient who had erythema elevatum diutinum as the first clinical evidence for diagnosing HIV infection. Bilaterally symmetric erythematous or violaceous plaques or nodules, often over outer surface of joints Systemically ill patients or associated with HIV May be related to granuloma faciale May be an immune-complex vasculitis induced by chronic antigen exposure.


EED lesions do not typically leave scars but can resolve with areas of hyperpigmentation or hypopigmentation. Authors Jessica Newburger ; George J. fritema

You can change the settings or obtain more information by clicking here. The cause of EED is not yet defined, but it has been associated with the following conditions:.

Arthralgias may develop in underlying joints, but extracutaneous involvement is extremely rare.

Eritema elevatum diutinum as a differential diagnosis of rheumatic diseases: case report.

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In his personal history, sexual promiscuity had been reported, although not drug addiction.

Erythema elevatum diutinum – Wikipedia

Antineutrophil cytoplasmic antibodies ANCA of the immunoglobulin G IgG type have proven useful for the diagnosis and monitoring of disease activity in various systemic vasculitides, including granulomatosis with polyangiitis Wegener’smicroscopic polyangiitis MPOpolyarteritis nodosa, and Churg—Strauss syndrome.

Vascular-related cutaneous conditions Cutaneous condition stubs. There is no significant mortality associated with EED. The exception includes ocular abnormalities such as scleritis, uveitis, autoimmune keratolysis, and peripheral keratitis.

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